The bubble nebula surrounding NGC 1313 X-2 is believed to be powered by high velocity winds from the central ultraluminous X-ray source (ULX) as a result of supercritical accretion. With the Multi-Unit Spectroscopic Explorer (MUSE) observation of the nebula, we find enhanced OIII emission at locations spatially coincident with clusters of stars and the central X-ray source, suggesting that photoionization in addition to shock-ionization plays an important role in powering the nebula. The X-ray luminosity of the ULX and the number of massive stars in the nebula region can account for the required ionizing luminosity derived with MAPPINGS V, which also confirms that pure shocks cannot explain the observed emission line ratios.