The Atacama Large Aperture Submillimeter Telescope (AtLAST) is a concept for a 50m class single-dish telescope that will provide high sensitivity, fast mapping of the (sub-)millimeter sky. Expected to be powered by renewable energy sources, and to be constructed in the Atacama desert in the 2030s, AtLAST's suite of up to six state-of-the-art instruments will take advantage of its large field of view and high throughput to deliver efficient continuum and spectroscopic observations of the faint, large-scale emission that eludes current facilities. Here we present the key science drivers for the telescope characteristics, and discuss constraints that the transformational science goals place on future instrumentation.